Season Six of Psych, consisting of 16 episodes, premiered on the USA Network in the United States on October 12, 2011, and continued to air until April 11, 2012. James Roday, Dulé Hill, Timothy Omundson, Maggie Lawson, Corbin Bernsen, and Kirsten Nelson all reprised their roles as the main characters.
Steve Franks continued to act as show runner of the series. The song "I Know, You Know", performed by The Friendly Indians, was used once again as the show's theme song, though it was edited three times for theme episodes: "The Amazing Psych-Man & Tap-Man, Issue 2" utilized a comic book-style theme song. A classic jazz variation was used in "Heeeeere's Lassie", while the version recorded by Boyz II Men for use in the Season Four episode "High Top Fade-Out " was played again in "Let's Doo-Wop It Again." Mel Damski returned to the series once again to direct three episodes, while Steve Franks and James Roday directed two each. John Badham, Andy Berman, Andrew Bernstein, Jay Chandrasekhar, David Crabtree, and Reginald Hudlin directed one episode each, while Timothy Busfield, Jennifer Lynch, and Brad Turner made their Psych directorial debuts in one episode each. Andy Berman, Todd Harthan, and Saladin K. Patterson wrote three episodes for the season. Kell Cahoon, Bill Callahan, Steve Franks, Tim Meltreger, and James Roday returned to the writing staff to pen two episodes each. Carlos Jacott joined the series to write one episode.
The season contained Indiana Jones and Chinatown tributes, along with a The Shining-themed episode. Series star Dulé Hill discussed the possibility of having another Twin Peaks themed episode, which would be a sequel to the Season Five episode "Dual Spires". A musical episode was also planned but was later confirmed to be on hold until the seventh season. Another theme episode revolving around the film Clue was also announced but was later pushed back to Season Seven as well. Production for the season began in late March 2011.
James Roday continued in his tenure as the fake psychic detective Shawn Spencer. Dulé Hill still portrayed Burton "Gus" Guster. Timothy Omundson and Maggie Lawson appeared as detectives Carlton "Lassie" Lassiter and Juliet "Jules" O'Hara, respectively. Corbin Bernsen portrayed Henry Spencer, and Kirsten Nelson returned as SBPD Chief Karen Vick.
Sage Brocklebank made further appearances as Buzz McNab. Kurt Fuller returned in many episodes as Woody the Coroner, while Skyler Gisondo and Carlos McCullers II returned as young Shawn and Gus in flashbacks. Cary Elwes returned as Pierre Despereaux for an Indiana Jones-themed episode. Jaleel White returned as Gus's former band mate, Tony. Kenan Thompson was expected to return as Joon, another band mate, but he did not appear; this disappearance was referenced in "Let's Doo-Wop It Again". Kristy Swanson appeared as Marlowe Viccellio, a mysterious woman who catches Lassiter's eye; she reprised her role in a later episode. Max Gail made his first appearance as Jerry Carp, one of Henry's cop friends. Carlos Jacott returned to the series but appeared in a different role than in his season one appearance. William Shatner appeared as Juliet's father Frank in two episodes. Other guest stars for the season include Mädchen Amick, Anthony Anderson, Diedrich Bader, Diora Baird, Wade Boggs, Wayne Brady, Lolita Davidovich, Brad Dourif, Rob Estes, Corey Feldman, Jennifer Finnigan, Miles Fisher, Danny Glover, Louis Gossett, Jr., Greg Grunberg, Julianna Guill, Tony Hale, Van Hansis, Glenne Headly, Whit Hertford, Jeff Hiller, Stoney Jackson, Matt Kaminsky, Suzanne Krull, Liza Lapira, Tom Lenk, Jocelyne Loewen, Ed Lover, Jessica Lucas, Cheech Marin, Malcolm McDowell, Joey McIntyre, Kate Micucci, Ivana Miličević, The Miz, Arden Myrin, Mekhi Phifer, Jason Priestley, John Rhys-Davies, Molly Ringwald, Sara Rue, Amanda Schull, Lindsay Sloane, French Stewart, Michael Trucco, and Polly Walker.
|Shawn Rescues Darth Vader||October 12, 2011||80|
|Last Night Gus||October 19, 2011||81|
Shawn, Gus, Lassiter and Woody wake up in the Psych office with no recollection of the night before. When a body is found, the quartet have to retrace their steps to exonerate themselves and find the real killer.
|This Episode Sucks||October 26, 2011||82|
Lassiter's new relationship with a mysterious and beautiful woman is placed in jeopardy when Shawn and Gus are convinced she is the murderer responsible for the blood-drained body the SBPD is investigating.
|The Amazing Psych-Man & Tap-Man, Issue 2||November 2, 2011||83|
|Dead Man's Curve Ball||November 9, 2011||84|
When the hitting coach of the local baseball team suddenly dies with amphetamines in his system, the team's manager hires Shawn and Gus to start an undercover investigation as the new coach and mascot.
|Shawn, Interrupted||November 16, 2011||85|
|In for a Penny...||November 30, 2011||86|
After upsetting Juliet by reuniting her with her estranged father without taking the time to learn that he's a con man, Shawn tries to assuage her by hiring him on a case to prove he's changed.
|The Tao of Gus||December 7, 2011||87|
|Neil Simon's Lover's Retreat||December 14, 2011||88|
|Indiana Shawn and the Temple of the Kinda Crappy, Rusty Old Dagger||February 29, 2012||89|
A valuable shipment of artifacts is stolen from a museum, so Shawn calls in Pierre Despereaux to help them catch the thief. However, they soon discover that one of the artifacts is the key to a much bigger mystery.
|Heeeeere's Lassie||March 7, 2012||90|
|Shawn and the Real Girl||March 14, 2012||91|
When a reality TV show contestant vying for the love of a bachelorette suffers a suspicious car crash, Shawn and Gus go undercover as two new contestants to find out who is behind the attempted murder.
|Let's Doo-Wop It Again||March 21, 2012||92|
|Autopsy Turvy||March 28, 2012||93|
|True Grits||April 4, 2012||94|
|Santabarbaratown||April 11, 2012||95|